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Prudchenko, et al (2021) DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion Biomedicines 2021, Volume 9 (Issue 4), Page 407

If a patient does not tolerate a dose increase, the prescribing information permits delaying escalation by an additional 4 weeks at the current dose

Adherence to this dosing schedule and regular monitoring are crucial for achieving optimal results and minimizing potential side effects

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Neuroimaging Studies Mechanistic neuroimaging studies using functional MRI have examined PT-141's effects on brain activation patterns during sexual stimuli presentation, showing that the peptide modulates activity in limbic and paralimbic regions involved in sexual arousal and motivation, providing objective evidence for its central mechanism of action